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Cannabis while pregnancy can affect children in adulthood

Devdiscourse News Desk 12 Sep 2018, 03:44 PM

London, Sep 12 (IANS) Maternal consumption of cannabinoids for pain relief during pregnancy can cause behavioral and neuronal deficits in males during adulthood, while females remain unaffected, says new research.

The study, conducted over rats, revealed that males exposed to cannabinoids while in the uterus were less sociable than normal animals, and spent less time interacting with others.

Their sniffing and playing behaviors were impaired, while the number of attacks among males remained unchanged.

In addition, the researchers saw that the exposed males had a heightened excitability of pyramidal neurons in the prefrontal cortex. However, none of these effects were seen in females.

"As cannabinoids can cross the placenta, they may interfere with fetal endocannabinoid signaling during neurodevelopment, which is involved in regulating a variety of processes such as pregnancy, appetite, pain sensation, and mediating the pharmacological effects of cannabis," said Olivier Manzoni, Research Director from the French National Institute of Health and Medical Research (INSERM) in Paris.

"This could, in turn, lead to some serious long-term deficits," Manzoni added.

For the study, published in eLife, the team examined how prenatal cannabinoid exposure influences the synaptic and behavioral functions of the medial prefrontal cortex -- a brain region often implicated in neuropsychiatric disorders -- in adult male and female rats.

While social interaction was specifically impaired in males, locomotion, anxiety, and cognition remained unaffected in both sexes, suggesting discrete and sex-specific behavioral consequences of cannabinoid exposure during adulthood, the researchers noted.

The results also revealed that the effects could be because of mGlu5 gene, which was reduced in the exposed males' prefrontal cortex.

Amplifying mGlu5 signaling could normalize the synaptic and behavioral deficits induced by prenatal exposure to cannabinoids partly by activating the cannabinoid type 1 receptor (CB1R).

Similarly, enhancing levels of anandamide (a type of endocannabinoid) in exposed males helped to restore their social deficits via CB1R.

The findings point towards a potential pharmacological strategy to help reverse social deficits in humans, the researchers stated.

(With inputs from agencies.)

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