Nathan MacKinnon scored twice, Tyson Jost, Colin Wilson and Carl Soderberg had goals 5 minutes, 35 minutes apart during the first frame to give Colorado its first road win of the season. Alex Kerfoot also scored, Mikko Rantanen had three assists and Semyon Varlamov stopped 30 shots for the Avalanche.
The Avalanche pulled out the win on its short two-game road trip with superior special teams. Colorado was 2-for-4 on the power play and killed all seven penalties it drew.
Jost got the Avalanche started with a goal at 10:55 of the first. With Jack McCabe in the box for hooking, Colorado moved the puck around the zone to Tyson Barrie at the point, who sent it to the net. Jost tipped it past Hutton for his first goal of the season.
Barrie had two assists on the night.
Soderberg made it 3-0 just 3:10 later when he beat McCabe with a high shot over the goaltender's left shoulder. It was his third goal of the season.
Buffalo thought it scored on the power play in the final minute of the first period but the goal was waived off for goaltender interference.
The Sabres finally got on the board late in the second period. Beaulieu took a shot from the point that went between Varlamov's pads and trickled through at 17:05. The celebration didn't last long. Just 28 seconds after Beaulieu's first goal of the season, MacKinnon scored to make it 4-1.
MacKinnon has scored at least one goal in each of Colorado's first four games.
Kerfoot and MacKinnon scored on breakaways late in the third period.
--Field Level Media
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