Pascal Siakam added 21 points while Fred VanVleet, CJ Miles and Delon Wright each scored 10.
Dwyane Wade scored a season-best 35 points off the bench for the Heat, losers of seven of the past nine games. Bam Adebayo added a double-double with 16 points and 21 rebounds, Josh Richardson scored 19 points, Kelly Olynyk had 11 and Wayne Ellington 10.
Richardson's 3-pointer with 19 seconds to play cut the margin to 10.
The Raptors led 36-29 after the first quarter in which they twice led by as many as 11 points while shooting 75 percent from the field.
The Heat reduced the deficit to two on Ellington's 3-pointer with 7:11 to play in the second quarter. Lowry's driving layup restored Toronto's 11-point advantage with 2:13 to play in the half. Toronto led 63-54 at halftime.
The Heat used a 10-2 rally finished by Olynyk's 3-pointer to cut the deficit to 15. Wade completed the third-quarter scoring with two free throws to pull the Heat to within 101-89.
--Field Level Media
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