Jackson suffered the injury during a Week 11 game against the New York Giants and has been trying to play through the ailment.
Earlier this week, he saw a hand specialist in Tampa and received a second opinion in New York. He returned to practice and was still having difficulties catching the ball.
The situation has added to Jackson's frustration level. There were reports he requested a trade earlier this season and his vocal support of quarterback Ryan Fitzpatrick furthered the perception that he isn't a fan of current starter Jameis Winston.
After some missed opportunities in last Sunday's victory over the San Francisco 49ers -- Jackson had three catches for 19 yards -- Koetter called for a meeting with Winston and Jackson.
"We went through the tape on the targets to DeSean where we missed him. You know, you're trying to find common ground," Koetter said. "We had DeSean open five other times and we didn't get the ball to him.
"We left a lot of yardage on the table when it came to just DeSean on routes that were designed to go to him or where the coverage dictated where it went."
Also, Koetter said that linebacker Lavonte David (knee) and rookie running back Ronald Jones II (hamstring) will play against the Panthers. David, the team's leading tackler (71), missed the past two games and Jones sat out the last four.
--Field Level Media
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