Embiid recorded his league-best 22nd double-double.
Ben Simmons had 13 points, 10 assists and eight rebounds. It was the 15th double-double this season for Simmons.
T.J. McConnell added 15 points, JJ Redick contributed 14 and Furkan Korkmaz had 13 for the Sixers, who improved to 12-1 at home and won their third in a row. Eight Sixers reached double figures in the win, half of them reserves.
Redick has now scored in double figures in 33 straight games, tying a career-best streak. Redick previously accomplished the feat from Feb. 25-Nov. 11, 2015 with the Clippers.
Mike Muscala and Landry Shamet scored 12 points apiece and Jimmy Butler had 11.
The Wizards fell to 2-9 on the road and dropped their second straight. They played without center Dwight Howard, who could be lost for several months after undergoing back surgery.
The Sixers surged to a 68-46 lead at halftime thanks in large part to dominance in rebounding. They held a 38-17 advantage on the boards in the half.
The Wizards shot just 18 of 48 from the field in the first half.
Butler knocked down a 3-pointer from the wing and the Sixers pulled ahead 73-49 early in the third. Redick later hit a jumper and the lead was 79-51 as the Wizards went scoreless for more than four-and-a-half minutes.
When Shamet drained a trey late in the third, the Sixers' lead swelled to 30 at 98-68.
Both teams emptied their benches for the entire fourth quarter as Shake Milton recorded the first field goal of his career for the Sixers.
The Wizards ran off a late 11-3 run but still trailed 119-92 with 2:45 remaining.
--Field Level Media
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