The Swiss squandered several set points in the opening set and although he took the second on a tiebreak he capitulated in the decider after dropping serve at 1-2, losing 7-5 6-7(3) 6-1.
His frustration boiled over as he buried his racket frame into the lush centre court turf, taking a sizeable divot in the process, before snapping it over his knee.
Wawrinka's ATP ranking has plummeted to 261 after his first-round loss at the French Open, having reached the final a year ago, but the good news is that his knees appear strong again after two surgeries last August.
He struck the ball with authority in the second set and played a solid tiebreak but his lack of sharpness told as he was sent packing by the fifth seed.
Querrey joined fellow American Frances Tiafoe in the last eight after he beat Argentine Leonardo Mayer 6-4 2-6 6-4.
Frenchman Jeremy Chardy maintained his impressive form on grass with a 7-6(6) 6-3 defeat of young Russian Danil Medvedev.
(This story has not been edited by Devdiscourse staff and is auto-generated from a syndicated feed.)