Alexis Ohanian, the internet entrepreneur and founder of Reddit, saluted the 36-year-old Williams for battling back from life-saving surgery to get within touching distance of an eighth Wimbledon title.
However, the American suffered a straight sets defeat to Angelique Kerber in Saturday's final.
"We just wanted her to survive - 10 months later, she's in the #Wimbledon final."
"Congratulations, @angie.kerber. @serenawilliams will be holding a trophy again soon - she's got the greatest one waiting at home for her," added Ohanian.
"Our family knows she'll win many more trophies, too. She's just getting started. And I couldn't be more proud."
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