Security personnel reacted slowly initially as the quartet, all identically dressed in white shirts, black trousers and black hats, ran on to the field from behind the French goal, trying to high-five players.
Croatia defender Dejan Lovren shoved one person to the ground before security personnel carried them off.
The interruption lasted no longer than two minutes, with play resuming at the 52-minute mark.
Eight years ago, a man wearing an anti-racism T-shirt ran on to the pitch minutes before the start of the 2010 World Cup final in Johannesburg and came very close to grabbing the trophy which was on display.
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