Protein that boosts survival in colon cancer patients identified
Scientists have identified a protein that boosts survival rates in colon cancer patients and could be targeted to treat the deadly disease.PTI | Updated: 21-07-2018 15:38 IST | Created: 21-07-2018 15:38 IST
The researchers examined the level of c-Cbl in tumors that were removed from people with colon cancer. Based on the level of this protein, c-Cbl, patients were split into two groups, high c-Cbl and low c-Cbl.
This off version of c-Cbl lacked an essential function of c-Cbl called ubiquitin ligase activity. Cells that were given the "off" version of c-Cbl grew more tumors than those that were given the "on" version.
For tumours to grow and metastasise they need blood vessels.
The next step was to look at how c-Cbl affected blood vessel growth by using three experimental models - one group was normal, one group was given the c-Cbl protein and the third group was given the "off" version of the protein.
The model that was given the "off" version of c-Cbl grew more blood vessels.
"This helps us to understand the role of the ubiquitin ligase activity of c-Cbl in preventing tumours from growing and reducing tumour's ability to grow blood vessels," said Vipul Chitalia, an associate professor at Boston University.
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