Left Menu
Development News Edition

New test better predicts which babies will develop type 1 diabetes

Scientists developed a method of combining multiple factors that could influence whether a child is likely to develop type 1 diabetes. The combined risk score approach incorporates genetics, clinical factors such as the family history of diabetes, and their count of islet autoantibodies -- biomarkers known to be implicated in type 1 diabetes.

ANI | Seattle | Updated: 09-08-2020 23:33 IST | Created: 09-08-2020 23:33 IST
New test better predicts which babies will develop type 1 diabetes
Representative image. Image Credit: ANI

Scientists developed a method of combining multiple factors that could influence whether a child is likely to develop type 1 diabetes. The combined risk score approach incorporates genetics, clinical factors such as the family history of diabetes, and their count of islet autoantibodies -- biomarkers known to be implicated in type 1 diabetes. The study led by scientists at the University of Exeter and the Pacific Northwest Research Institute in Seattle used the TEDDY data. Scientists at seven international sites have followed 7,798 children at high risk of developing type 1 diabetes from birth, over nine years, in The Environmental Determinants of Diabetes in the Young (TEDDY) Study. The TEDDY Study is a large international study funded primarily by the US National Institutes of Health and U.S. Centers for Disease Control, as well as by the charity JDRF.

In research published in Nature Medicine, the research team found that the new combined approach dramatically improved prediction of which children would develop type 1 diabetes, potentially allowing better diabetes risk counselling of families. Most importantly, the new approach doubled the efficiency of programmes to screen newborns to prevent the potentially deadly condition of ketoacidosis, a consequence of type 1 diabetes in which insulin deficiency causes the blood to become too acidic. Identifying which children are at the highest risk will also benefit clinical trials on drugs that are showing promise in preventing the condition. Dr Lauric Ferrat at the University of Exeter Medical School said: "At the moment, 40 per cent of children who are diagnosed with type 1 diabetes have the severe complication of ketoacidosis. For the very young this is life-threatening, resulting in long intensive hospitalizations and in some cases even paralysis or death. Using our new combined approach to identify which babies will develop diabetes can prevent these tragedies, and ensure children are on the right treatment pathway earlier in life, meaning better health."

Professor William Hagopian of the Pacific Northwest Research Institute, said: "We're really excited by these findings. They suggest that the routine heel prick testing of babies done at birth could go a long way towards preventing early sickness as well as predicting which children will get type 1 diabetes years later. We're now putting this to the test in a trial in Washington State. We hope it will ultimately be used internationally to identify the condition as early as possible, and to power efforts to prevent the disease." Researchers believe the combined approach can also be rolled out to predict the onset of other diseases with a strong genetic component that is identifiable in childhood, such as celiac disease.

Sanjoy Dutta, JDRF Vice President of Research, said:" We know that while genetics have a strong correlation as a risk factor for family members to develop T1D, most newly diagnosed individuals do not have a known family history. JDRF has been exploring the non-genetic, environmental risk factors that trigger T1D to help develop treatments to forestall or prevent disease onset." (ANI)


TRENDING

OPINION / BLOG / INTERVIEW

Post-COVID-19 Nigeria needs a robust Health Management Information System to handle high disease burden

Nigeria is among a few countries that conceptualised a health management information system HMIS in the early 90s but implementation has been a challenge till date. Besides COVID-19, the country has a huge burden of communicable and non-com...

Morocco COVID-19 response: A fragile health system and the deteriorating situation

Learning from its European neighbors, Morocco imposed drastic measures from the initial stages of the COVID-19 outbreak to try to contain its spread. The strategy worked for a few months but the cases have surged after mid-June. In this sit...

COVID-19: Argentina’s health system inefficiencies exaggerate flaws of health information system

You can recover from a drop in the GDP, but you cant recover from death, was the straightforward mindset of Argentinas President Alberto Fernndez and defined the countrys response to COVID-19. The South American nation imposed a strict...

Videos

Latest News

NEWSMAKER-U.S. Supreme Court nominee Barrett has staked out conservative positions

In nominating Amy Coney Barrett for a lifetime job on the U.S. Supreme Court, President Donald Trump has selected a federal appeals court judge who has staked out conservative legal positions on key hot-button issues in three years on the b...

FACTBOX-Noteworthy legal opinions from Trump's Supreme Court pick Barrett

Amy Coney Barrett, President Donald Trumps nominee for a lifetime job on the U.S. Supreme Court, has served as a federal appeals court judge since 2017 and has weighed in on cases involving several hot-button issues including abortion, gun ...

'Brilliant and gifted': Trump makes conservative judge Barrett his Supreme Court pick

President Donald Trump on Saturday announced conservative appellate judge Amy Coney Barrett as his third U.S. Supreme Court appointment, setting off a scramble in the Republican-led Senate to confirm her before Election Day in 5-12 weeks. B...

Thousands march in Washington to pray and show Trump support

Thousands of people packed the National Mall in downtown Washington on Saturday to pray and show their support for President Donald Trump. The march, which stretched from the Lincoln Memorial to the US Capitol, was held just hours before Tr...

Give Feedback