Nobel Prize Triumph: Scientists Unlock Immune System Secrets

Mary Brunkow, Fred Ramsdell, and Shimon Sakaguchi won the 2025 Nobel Prize in Physiology or Medicine for their discoveries in peripheral immune tolerance. Their work on regulatory T cells has spurred new treatments for autoimmune diseases and cancer, showcasing the immune system's control mechanisms.

American scientists Mary Brunkow and Fred Ramsdell, alongside Japan's Shimon Sakaguchi, have taken home the coveted 2025 Nobel Prize in Physiology or Medicine. They were recognized for groundbreaking discoveries in peripheral immune tolerance, a development that opens new doors for treating autoimmune diseases and cancer.

Their work, detailing how regulatory T cells act as immune system guards, has implemented a fresh research foundation. This pivotal breakthrough is acclaimed for helping the body control its immune responses, preventing self-attacks from immune cells, an achievement highlighted by the prize-awarding body.

Sakaguchi expressed immense honor at the recognition, having been informed of the win at his lab. The laureates receive 11 million Swedish crowns and a gold medal, reinforcing the significance of their contributions to medical science.

(With inputs from agencies.)