Patients switching to Novo Nordisk's Wegovy pill from shots lose more weight in real-world study

Patients who switched from weight-loss injections to Novo Nordisk's daily ​Wegovy pill continued to lose weight, according to data ​unveiled at a medical meeting on Wednesday, ‌as the ​Danish drugmaker seeks to defend its lead over US rival Eli Lilly in the market for oral obesity treatments.

Study participants lost an average of 4.1% of their body weight ‌over three months after transitioning from injectable obesity therapies — including Wegovy and Lilly's Zepbound — to oral semaglutide, the active ingredient in Wegovy, as well as Ozempic. Patients lost an average of 4.0 kg (8.8 pounds) from a baseline weight of 221.6 pounds (100.5 kg) after making the switch, ‌and the proportion of participants classified as clinically obese dropped to 65.5% from 87.1% after three months, with nearly 41% ‌shedding at least 5% of their body weight.

"There's been a lot of questions on can people be compliant to the pill? Do people really prefer the pill? Clearly, a lot of patients do even better on the pill than they did on the (injectable) drugs, and I think that ⁠is strong ​data," said Novo's Chief Scientific Officer ⁠Martin Holst Lange in an interview. Detailed data from the 194-patient, real-world study was presented at the European Association for the Study of Diabetes meeting in Milan.

PILL ⁠BRINGS NOVO RELIEF Novo's fortunes have reversed sharply since it became Europe's most valuable listed company following the 2021 launch of injectable Wegovy for ​weight loss. Its shares have tumbled more than 70% from their peak, as Lilly has overtaken Novo as the obesity-drug ⁠market leader.

The company has found some relief with the Wegovy pill. Oral therapies now account for about a third of US obesity prescriptions following the ⁠pill's ​rollout, according to company presentations earlier this month, with Novo capturing more than 80% of new oral prescriptions. Novo CEO Mike Doustdar told Reuters last week that weight-loss pills could capture as much as half of the global obesity-drug market, which analysts ⁠estimate could be worth $100 billion annually or more by the end of the decade.

The data was compiled in collaboration with ⁠US telehealth company Ro. While real-world ⁠findings reflect actual clinical practice, they rely in part on patient self-reporting and cannot establish direct causality as randomized trials can. The Wegovy pill has launched in the US, Britain, Germany, and ‌the UAE, with ‌rollouts in additional markets planned in coming quarters.