The incident occurred near Lakshmipuram village of Challapalli Mandal in Krishna district.
The deceased were identified as Gouse (26) and Prasad (25), residents of Machilipatnam and Challapalli areas.
According to police, Gouse and his friend Javeed were on their way to Machilipatnam from Challapalli on a two-wheeler when a motorcycle ridden by Prasad collided with their vehicle.
Gouse and Prasad died on the spot while Javeed was injured and admitted to the district hospital in Machilipatnam, Challapalli Sub Inspector B Srinivasa Rao said.
A case has been registered in the Challapalli police station and investigation is on, Rao said.
He said police sent the bodies to Avanigadda government hospital for post-mortem. DPB
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