FACTBOX-Latest on the worldwide spread of the coronavirus

* China's National Health Commission said COVID-19 has contributed to the decline in the country's marriage and birth rates that has accelerated in recent years due to the high costs of education and child-rearing. * China reported 1,895 new COVID-19 infections on Aug. 22, of which 382 were symptomatic and 1,513 were asymptomatic, the National Health Commission said on Tuesday.

Dr. Anthony Fauci, the top U.S. infectious disease official who became the face of America's COVID-19 pandemic response under Presidents Donald Trump and Joe Biden, said on Monday he was stepping down in December after 54 years of public service. DEATHS AND INFECTIONS

* Eikon users, click on COVID-19: MacroVitals for a case tracker and summary of the news. cpurl://apps.cp./cms/?navid=1592404098 ASIA-PACIFIC

* Japan may lift requirements for pre-departure COVID-19 tests for travelers entering the country, the Nikkei newspaper reported. * China's National Health Commission said COVID-19 has contributed to the decline in the country's marriage and birth rates that has accelerated in recent years due to the high costs of education and child-rearing.

* China reported 1,895 new COVID-19 infections on Aug. 22, of which 382 were symptomatic and 1,513 were asymptomatic, the National Health Commission said on Tuesday. * Shanghai reported three new domestically transmitted asymptomatic coronavirus cases for Aug. 22, the same as a day earlier, and one local symptomatic case, also the same as a day earlier, the city government said on Tuesday.

AMERICAS * Mexico will file a complaint to the United Nations over the failure to deliver vaccines against COVID-19 that the government bought under a program backed by the World Health Organization, President Andres Manuel Lopez Obrador said on Monday.

* Moderna Inc said it will supply 12 million doses of its variant-adapted shot that targets the Omicron version of the coronavirus to Canada. * The U.S. Centers for Disease Control and Prevention on Monday signed off on the use of Novavax Inc's vaccine for adolescents aged 12 through 17.

MEDICAL DEVELOPMENTS * Pfizer Inc and German partner BioNTech said on Monday they had sought U.S. authorization for a COVID-19 vaccine booster retooled to target the Omicron variant and would have doses available to ship immediately after regulatory clearance.

* Swiss pharma company Roche Holding launched a COVID-19 test that detects and differentiates the emerging variant of interest BA.2.75. ECONOMIC IMPACT

* Asian shares were down for a sixth straight session on Tuesday after a renewed spike in European energy prices stoked fears of recession and pushed bond yields higher, while tipping the euro to 20-year lows. * Japan's factory activity growth slowed to a 19-month low in August as output and new order declines deepened, amid growing pressure from persistent rises in raw material and energy costs and weakening global demand.