Japanese Researchers Uncover Key Blood Marker Linked to Autism

Scientists from Japan's University of Fukui have identified a neonatal blood marker, 11,12-diHETrE, that may influence autism spectrum disorder (ASD) severity and adaptive functioning in children. This discovery could pave the way for early ASD diagnosis and intervention, potentially improving outcomes for affected individuals.

Japanese researchers have made a significant breakthrough in understanding autism spectrum disorder (ASD). A team from the University of Fukui found that levels of a specific compound, 11,12-dihydroxyeicosatrienoic acid (diHETrE), in neonatal umbilical cord blood can significantly impact ASD symptoms and adaptive functioning in children.

Led by Professor Hideo Matsuzaki, the study analyzed umbilical cord blood from 200 children, correlating the levels of diHETrE with ASD symptoms assessed at age six. The results indicate that high levels of 11,12-diHETrE are linked to severe social interactions deficits, while low levels of 8,9-diHETrE are associated with repetitive behaviors, especially in girls.

Prof. Matsuzaki's team suggests that early detection and intervention could be possible by measuring diHETrE levels at birth. Additionally, inhibiting diHETrE metabolism during pregnancy might reduce the likelihood of ASD traits. These findings could revolutionize ASD diagnosis and treatment, offering hope for more effective early interventions.