Left Menu
Development News Edition

IIT scientists create mini-organs that mimic hair growth

Scientists from IIT Delhi have developed a silk-based hydrogel that emulates the process of hair growth, an advance that may help screen novel drugs for treating hair loss without using animal tests.

PTI | Updated: 16-07-2018 13:54 IST | Created: 16-07-2018 13:54 IST

Scientists from IIT Delhi have developed a silk-based hydrogel that emulates the process of hair growth, an advance that may help screen novel drugs for treating hair loss without using animal tests.

A study, published in the Journal of Cellular Physiology, shows how the three-dimensional mini organs can mimic the different stages of hair growth in humans.

Hair loss is a common ailment, and can be stressful for the people experiencing it. A number of factors including genes, illness, trauma and surgeries can lead to temporary or permanent hair loss.

However, alopecia - condition that occurs due to abnormal growth cycle or reduction in the size of hair follicles - is the major reason contributing to permanent hair loss, researchers said.

Numerous oils, creams, and medicines are commercially available but successful treatment of alopecia is still a far-fetched dream.

"The major reason for such inefficiency is there is no suitable human cell-based in vitro models available for drug testing. The currently available anti-alopecia drugs and cosmetics are tested on animals," said Sourabh Ghosh, an

associate professor at Indian Institute of Technology (IIT) Delhi.

"But, due to the differences in the immunology and physiology amongst animals and humans drastically limit the success of such drugs," Ghosh told PTI.

"We strongly felt the need to develop an ideal three dimension in vitro model of hair follicle using human cells," he said.

Such models offer tremendous potential as rapid drug and cosmetic testing tools, results of which can be successfully extrapolated in humans.

If successful, such drugs would tend to solve the unending needs of the persons suffering from hair loss thus improving the aesthetic as well as physiological state of the patients, Ghosh said.

The team, which included researchers from the ITC Life Sciences and Technology Centre in Bangalore, developed the hydrogel by combining a mixture of silk proteins, isolated from silkworm cocoons, and gelatin. Tyrosinase enzyme was used to develop a stable hydrogel system.

"The system provided an ideal environment to develop a complete 3D model of hair follicle regeneration," Ghosh said.

"Since we have already successfully tested the action of a model hair regeneration drug (minoxidil) in our lab based hair follicle model, we strongly feel that our hair follicle model is ready to be used by companies to test their products," he said.

(This story has not been edited by Devdiscourse staff and is auto-generated from a syndicated feed.)



China: A savior for emerging markets or a poison pill?

... ...

Future of Urban Planning: Artificial Intelligence guiding the way

Advances in emerging technologies like Artificial Intelligence and Machine Learning can help us understand our cities better and derive useful insights from real-time data collected through automated models....


Latest News

EU says very concerned about Russian arrests

The European Unions top diplomat said on Monday that the more than 3,000 people arrested across Russia on Saturday was of great concern and that EU foreign ministers would discuss their response in the next hours.We will deal with the worry...

China stocks close higher as consumer firms lend support

China shares ended higher on Monday, underpinned by consumer and liquor stocks, though gains were limited by Sino-U.S. tensions. The blue-chip CSI300 index rose 1 to 5,625.92, while the Shanghai Composite Index added 0.5 to 3,624.24. Leadi...

PMLA case: HC refuses bail to Yes Bank founder Rana Kapoor

The Bombay High Court on Mondayrefused to grant bail to Yes Bank founder Rana Kapoor, who isaccused in a case of money laundering.Kapoor was arrested in March last year by theEnforcement Directorate ED.The central agency is conducting an in...

Indonesia's coast guard seizes Iranian and Panamanian tankers

Indonesia said on Sunday its coast guard had seized the Iranian-flagged MT Horse and the Panamanian-flagged MT Freya vessels over suspected illegal fuel transfers off the countrys waters.A statement from coast guard spokesman Wisnu Pramandi...

Give Feedback