Trailblazing Discoveries in Peripheral Immune Tolerance Win Nobel

Mary Brunkow, Fred Ramsdell, and Shimon Sakaguchi have been awarded the 2025 Nobel Prize in Physiology or Medicine for their significant discoveries in peripheral immune tolerance. The prize, conferred by Sweden’s Karolinska Institute, includes a reward of 11 million Swedish crowns, equivalent to $1.2 million, and a gold medal.

Mary Brunkow, Fred Ramsdell, and Shimon Sakaguchi have been honored with the 2025 Nobel Prize in Physiology or Medicine for groundbreaking discoveries in peripheral immune tolerance.

These findings were acknowledged by the Nobel Assembly of Sweden’s prestigious Karolinska Institute, a leading global authority in the medical community.

The laureates will share a prize sum of 11 million Swedish crowns ($1.2 million), alongside a gold medal presented by Sweden’s monarch during an official ceremony.