The Dow Jones Industrial Average on Monday fell 181.45 points, or 0.68 percent, to 26,562.05. The S&P 500 was down 10.30 points, or 0.35 percent, to 2,919.37, Xinhua news agency reported.
The Nasdaq Composite Index rose 6.29 points, or 0.08 percent, to 7,993.25.
Shares of Caterpillar and Boeing, companies with high overseas revenue exposure, both declined more than 1 percent, at the close.
Exxon Mobil and Apple were among the best performers in the Dow. Shares of the companies advanced 1.68 percent and 1.44 percent, respectively.
Seven of the 11 primary S&P 500 sectors traded lower, with real estate and consumer staples leading the losers. Tech sector closed more than 0.3 percent higher, underpinning the Nasdaq.
The CFNAI is a weighted average of 85 existing monthly indicators of national economic activity. A positive index reading corresponds to growth above trend and a negative index reading indicates growth below trend.