Among the arrested were four vehicle examiners and cashiers.
"It is alleged that the six colluded in issuing roadworthy certificates to vehicles that they never tested. False identity documents were allegedly used to generate the certificates on the National Traffic Information System," the RTMC said in the statement.
"The six suspects are expected to remain in custody for at least seven days before being granted bail. Bail will be opposed when they make their first appearance tomorrow," said the RTMC.
"It is significant that these arrests happened on the same day that the national Easter road safety campaign is launched. Fighting fraud and corruption is a critical part of our drive to make roads safer. We reiterate to all our road users to play their part to reduce road carnage in our country," said RTMC chief executive Makhosini Msibi.
(With Inputs from South African Government Press Release)