FACTBOX-Latest on the worldwide spread of coronavirus

* A surge in demand for vaccines to ward off the winter flu has led to shortages in some European cities, raising the risk of a potentially lethal "twindemic" as COVID-19 cases soar. * Spain's health minister described a second wave sweeping the county as "out of control." * British PM Boris Johnson said England's test and trace scheme needed improvement after a record low proportion of contacts of positive cases were reached in the latest weekly figures. * Germany has issued travel warnings for popular ski regions in Austria, Italy and Switzerland.

The U.S. Food and Drug Administration approved Gilead Sciences Inc's antiviral drug remdesivir for treating patients hospitalized with COVID-19, making it the first and only drug approved for the disease.

DEATHS AND INFECTIONS * For an interactive graphic tracking the global spread of COVID-19, open https://graphics.reuters.com/world-coronavirus-tracker-and-maps/ in an external browser.

* Eikon users, see COVID-19: MacroVitals https://apac1.apps.cp.thomsonreuters.com/cms/?navid=1592404098 for a case tracker and summary of news. EUROPE

* France extended curfews to around two-thirds of its population and Belgium's foreign minister was taken into intensive care with COVID-19, as the second wave of the pandemic surged across Europe. * A surge in demand for vaccines to ward off the winter flu has led to shortages in some European cities, raising the risk of a potentially lethal "twindemic" as COVID-19 cases soar.

* Spain's health minister described a second wave sweeping the county as "out of control." * British PM Boris Johnson said England's test and trace scheme needed improvement after a record low proportion of contacts of positive cases were reached in the latest weekly figures.

* Germany has issued travel warnings for popular ski regions in Austria, Italy and Switzerland. * Croatia, Slovenia and Bosnia reported their biggest one-day rises in cases.

* Greece will impose a night curfew in areas most affected by COVID-19. AMERICAS

* Several U.S. states, many of them in the Midwest, reported record single-day increases in cases, further evidence that the pandemic is accelerating anew as cooler weather takes hold in many parts of the country. * U.S. House Speaker Nancy Pelosi said negotiators were making progress in talks with the Trump administration for another round of COVID-19 stimulus.

* Canada and the Alberta province are launching a pilot program to test eligible returning travelers for COVID-19, allowing them to leave quarantine once they receive a negative result. ASIA-PACIFIC

* Indian Prime Minister Narendra Modi's party promised free doses of any future COVID-19 vaccine for the residents of eastern Bihar state if it wins local elections there, drawing accusations of playing politics with the pandemic. MIDDLE EAST AND AFRICA

* Ethiopia can jail people for up to two years if they deliberately violate COVID-19 restrictions, the attorney general's office said, amid concern that citizens are becoming lax after a state of emergency was lifted. MEDICAL DEVELOPMENTS

* Moderna Inc has completed enrolling 30,000 participants in a late-stage study testing its experimental coronavirus vaccine. * AstraZeneca's Oxford COVID-19 vaccine accurately follows the genetic instructions programmed into it by its developers to successfully provoke a strong immune response, according to a detailed analysis carried out by independent UK scientists.

ECONOMIC IMPACT * The number of Americans filing new claims for unemployment benefits fell more than expected last week, but remained very high as the labor market recovery shows signs of strain.

* Europe's biggest economy could grow next year if Germany avoids a second lockdown, Economy Minister Peter Altmaier said. * American Airlines and Southwest Airlines signaled that they would continue to hemorrhage cash into next year.