Oxford says vaccine has good immune response with two-dose regime

Oxford's COVID-19 vaccine candidate has a better immune response when a two full-dose regime is used rather than a full-dose followed by a half-dose booster, the university said on Thursday. The vaccine candidate, which has been licensed to AstraZeneca, has published interim late stage trial results showing higher efficacy when a half dose is followed by a full dose, compared to a two full-dose regime, though more work needs to be done to affirm the result.

Oxford's COVID-19 vaccine candidate has a better immune response when a two full-dose regime is used rather than a full-dose followed by a half-dose booster, the university said on Thursday.

The vaccine candidate, which has been licensed to AstraZeneca, has published interim late-stage trial results showing higher efficacy when a half dose is followed by a full dose, compared to a two full-dose regime, though more work needs to be done to affirm the result. The details from the Phase I/II clinical trials released on Thursday made no reference to the half-dose/full-dose regime, which Oxford has said had been "unplanned" but approved by regulators.

The university said it had explored two dosing regimes in early stage trials, a full-dose/full-dose regime and a full-dose/half-dose regime, investigated as a possible "dose sparing" strategy. "The booster doses of the vaccine are both shown to induce stronger antibody responses than a single dose, the standard dose/standard dose inducing the best response," the university said in a statement.

The vaccine "stimulates broad antibody and T cell functions," it said after publishing further data from the Phase I/II clinical trials.