FACTBOX-Latest on the worldwide spread of the coronavirus

* Britain, which will this week begin offering vaccinations to children aged 5-11 who are most at risk from coronavirus, is also looking at possibly changing rules on mandatory vaccination for health service staff. AMERICAS * The U.S. CDC advised against travel to a dozen destinations, including Mexico, Brazil, Singapore, Ecuador, Kosovo, Philippines and Paraguay. * Canadian Prime Minister Justin Trudeau said on Monday he had tested positive for COVID-19 but was feeling fine and would continue to work remotely while following public health guidelines.

British Prime Minister Boris Johnson apologised and vowed to "fix it" after a report on Monday into lockdown parties held at his Downing Street residence criticised serious failures at the heart of government. DEATHS AND INFECTIONS

* Eikon users, see COVID-19: MacroVitals https://apac1.apps.cp.thomsonreuters.com/cms/?navid=1592404098 for a case tracker and summary of news. EUROPE

* Romania will from Tuesday drop a demand for travellers to quarantine if they are vaccinated, have proof of recovery from COVID-19 or can provide a negative test result, regardless of where they are coming from. * The BA.2 subvariant of the Omicron coronavirus variant, which has quickly taken over in Denmark, is more transmissible than the more common BA.1 and more able to infect vaccinated people, a Danish study has found.

* The German government has failed to hit its goal of vaccinating 80% of the population against the coronavirus before the end of January, roughly a month before lawmakers are expected to vote on a draft law on mandatory vaccinations. * Britain, which will this week begin offering vaccinations to children aged 5-11 who are most at risk from coronavirus, is also looking at possibly changing rules on mandatory vaccination for health service staff.

AMERICAS * The U.S. CDC advised against travel to a dozen destinations, including Mexico, Brazil, Singapore, Ecuador, Kosovo, Philippines and Paraguay.

* Canadian Prime Minister Justin Trudeau said on Monday he had tested positive for COVID-19 but was feeling fine and would continue to work remotely while following public health guidelines. * Dozens of trucks and other vehicles blocked the downtown area of Ottawa for a second day after thousands descended on Canada's capital city on Saturday to protest against Prime Minister Justin Trudeau and COVID-19 vaccine mandates.

ASIA-PACIFIC * During the past four days China has detected 119 COVID-19 cases among athletes and personnel involved in the Beijing Winter Olympics, with authorities imposing a "closed loop" bubble to keep participants, staff and media separated from the public.

* Indonesia's holiday island of Bali will start welcoming back travellers from all countries later this week, more than three months after announcing it was open to selected nationalities. AFRICA AND MIDDLE EAST

* South Africa no longer requires those who test positive for COVID-19 without symptoms to isolate and has also reduced the isolation period for those with symptoms by three days, as the country exits its fourth COVID-19 wave. MEDICAL DEVELOPMENTS

* The U.S. FDA gave full approval to Moderna Inc's COVID-19 vaccine for people age 18 and older, making it the second fully approved vaccine for the virus. * Novavax Inc said it had filed for a U.S. approval for the emergency use of its COVID-19 vaccine in adults, a much-awaited step for the company following months of struggles with development and manufacturing problems.

* Merck & Co's new antiviral pill, once touted as a potential game changer for treating COVID-19, is the last choice among four available options for at-risk patients given its relatively low efficacy and potential safety issues, U.S. doctors, healthcare systems and pharmacies told Reuters. * Japanese trading and pharmaceutical company Kowa Co Ltd anti-parasite drug ivermectin showed an "antiviral effect" against Omicron and other variants of coronavirus in joint non-clinical research.

ECONOMIC IMPACT * World stocks staged a modest rebound as traders put aside concerns about interest rate rises and the crisis in Ukraine to dip back in, but global equities are still headed for their worst January since 2016 after a bruising month.

(Compiled by Marta Frackowiak and Krishna Chandra Eluri; Editing by Milla Nissi and Anil D'Silva)