Left Menu
Development News Edition

New test better predicts which babies will develop type 1 diabetes

Scientists developed a method of combining multiple factors that could influence whether a child is likely to develop type 1 diabetes. The combined risk score approach incorporates genetics, clinical factors such as the family history of diabetes, and their count of islet autoantibodies -- biomarkers known to be implicated in type 1 diabetes.

ANI | Seattle | Updated: 09-08-2020 23:33 IST | Created: 09-08-2020 23:33 IST
New test better predicts which babies will develop type 1 diabetes
Representative image. Image Credit: ANI

Scientists developed a method of combining multiple factors that could influence whether a child is likely to develop type 1 diabetes. The combined risk score approach incorporates genetics, clinical factors such as the family history of diabetes, and their count of islet autoantibodies -- biomarkers known to be implicated in type 1 diabetes. The study led by scientists at the University of Exeter and the Pacific Northwest Research Institute in Seattle used the TEDDY data. Scientists at seven international sites have followed 7,798 children at high risk of developing type 1 diabetes from birth, over nine years, in The Environmental Determinants of Diabetes in the Young (TEDDY) Study. The TEDDY Study is a large international study funded primarily by the US National Institutes of Health and U.S. Centers for Disease Control, as well as by the charity JDRF.

In research published in Nature Medicine, the research team found that the new combined approach dramatically improved prediction of which children would develop type 1 diabetes, potentially allowing better diabetes risk counselling of families. Most importantly, the new approach doubled the efficiency of programmes to screen newborns to prevent the potentially deadly condition of ketoacidosis, a consequence of type 1 diabetes in which insulin deficiency causes the blood to become too acidic. Identifying which children are at the highest risk will also benefit clinical trials on drugs that are showing promise in preventing the condition. Dr Lauric Ferrat at the University of Exeter Medical School said: "At the moment, 40 per cent of children who are diagnosed with type 1 diabetes have the severe complication of ketoacidosis. For the very young this is life-threatening, resulting in long intensive hospitalizations and in some cases even paralysis or death. Using our new combined approach to identify which babies will develop diabetes can prevent these tragedies, and ensure children are on the right treatment pathway earlier in life, meaning better health."

Professor William Hagopian of the Pacific Northwest Research Institute, said: "We're really excited by these findings. They suggest that the routine heel prick testing of babies done at birth could go a long way towards preventing early sickness as well as predicting which children will get type 1 diabetes years later. We're now putting this to the test in a trial in Washington State. We hope it will ultimately be used internationally to identify the condition as early as possible, and to power efforts to prevent the disease." Researchers believe the combined approach can also be rolled out to predict the onset of other diseases with a strong genetic component that is identifiable in childhood, such as celiac disease.

Sanjoy Dutta, JDRF Vice President of Research, said:" We know that while genetics have a strong correlation as a risk factor for family members to develop T1D, most newly diagnosed individuals do not have a known family history. JDRF has been exploring the non-genetic, environmental risk factors that trigger T1D to help develop treatments to forestall or prevent disease onset." (ANI)


TRENDING

OPINION / BLOG / INTERVIEW

Post-COVID-19 Nigeria needs a robust Health Management Information System to handle high disease burden

Nigeria is among a few countries that conceptualised a health management information system HMIS in the early 90s but implementation has been a challenge till date. Besides COVID-19, the country has a huge burden of communicable and non-com...

Morocco COVID-19 response: A fragile health system and the deteriorating situation

Learning from its European neighbors, Morocco imposed drastic measures from the initial stages of the COVID-19 outbreak to try to contain its spread. The strategy worked for a few months but the cases have surged after mid-June. In this sit...

COVID-19: Argentina’s health system inefficiencies exaggerate flaws of health information system

You can recover from a drop in the GDP, but you cant recover from death, was the straightforward mindset of Argentinas President Alberto Fernndez and defined the countrys response to COVID-19. The South American nation imposed a strict...

Rwanda’s COVID-19 response commendable but health information system needs improvement

Rwanda is consistently working to improve its health information system from many years. However, it is primarily dependent on the collection and reporting of health data on a monthly basis. Besides, evaluation studies on Rwandas HIS publis...

Videos

Latest News

BLM gets first mention at UN's virtual gathering

South African President Cyril Ramaphosa is the first world leader at the United Nations annual gathering to mention the Black Lives Matter movement. As a country that has known too well the anguish of institutional racism, South Africa supp...

LS passes three labour codes; Gangwar says reforms to boost investment, widen social security net under ESIC, EPFO

Lok Sabha on Tuesday passed three labour code legislations which envisage covering over 50 crore workers from organized, unorganized and self-employed categories for minimum wages and social security. The Occupational Safety, Health and Wor...

Polish town votes to stay 'LGBT-free zone' despite global criticism

Councillors in eastern Poland voted narrowly on Tuesday to keep a motion declaring their town free from LGBT ideology, as international pressure grows on dozens of Polish municipalities that have made similar declarations. The mayors office...

Maha: Death toll in Bhiwandi building collapse rises to 25

The death toll in the Bhiwandi building collapse in Maharashtra rose to 25 on Tuesday, with the recovery of a dozen more bodies overnight, police said. The number of those rescued has gone up to 25, with five more persons being pulled alive...

Give Feedback