Left Menu
Development News Edition

Researchers including one of Indian-origin identify three novel genetic variants

Devdiscourse News Desk | Updated: 05-10-2018 00:30 IST | Created: 28-09-2018 14:02 IST
Researchers including one of Indian-origin identify three novel genetic variants
The study, published in the journal PLOS Genetics, links the risk for back pain with variants in genes controlling skeletal development, among other pathways. (Image Credit: Twitter)

Researchers, including one of Indian-origin, have identified three novel genetic variants associated with chronic back pain that may help point toward avenues for the eventual development of new therapies.

The study, published in the journal PLOS Genetics, links the risk for back pain with variants in genes controlling skeletal development, among other pathways.

"Chronic back pain is linked to changes in mood, and the role of the central nervous system in the transition from acute to chronic back pain is well-recognized," said the co-author Pradeep Suri from the University of Washington.

"However, the top two genetic variants we identified suggest causes implicating the peripheral structures, such as the spine," Suri added.

For the study, the research team involved 158,000 adults of European ancestry, including over 29,000 individuals with chronic back pain, looking for gene variants that were associated with the presence of back pain.

The strongest association was with a variant in the SOX5 gene, which is a transcription factor involved in virtually all phases of embryonic development.

Inactivation of SOX5 has previously been linked to defects in cartilage and skeleton formation in mice, supporting the hypothesis that the variant discovered in this study may contribute to chronic back pain through its influence on some aspect of skeletal development.

The association of the SOX5 variant with chronic back pain was replicated in another group of over 280,000 individuals, including over 50,000 individuals with chronic back pain.

A second gene, previously associated with intervertebral disc herniation, was also linked to back pain, as was a third gene that plays a role in spinal cord development, possibly implicating pain sensation or mood in the risk for back pain.

"The results of our genome-wide association study point to multiple pathways that may influence risk for chronic back pain," Suri said.

"We expect that further large-scale genetic studies will reveal the importance of both peripheral and central contributors to the complex experience of chronic back pain," Suri noted.


TRENDING

OPINION / BLOG / INTERVIEW

5G will be the key driving force for COVID-19 recovery: Here's how?

... ...

Canada’s COVID-19 pitfalls highlight need for integrated health information system

In the globalized world of today where outbreaks can spread far and wide within a matter of days, a global-level integrated health information system is ideal but Canadas provincial barriers show that the country lags much behind in deployi...

Pandemic must be impetus, not obstacle, for clean water access

To make matters worse, there are suspicions that the inadequacy of wastewater treatment methods in California, the rest of the USA, and indeed around the world may help to propagate the disease even more widely. ...

3D printing and the future of manufacturing post COVID-19

The on-demand, customizable, and localized manufacturing of product components facilitated by 3D printing has the potential to redefine manufacturing but there are certain technical, mechanical, and legal limitations that, unless ...

Videos

Latest News

Naval and Coast Guard ships dressed with signalling flags in Kochi

In the absence of ceremonial parade in the wake of COVID-19 pandemic, Naval and Coast Guard ships at Kochi were dressed with signalling flags and pennants in a ceremonial manner as a customary method of celebration on Independence Day on Sa...

Once we get vaccine, Covid warriors will be first ones to get dose: MoS Health

Scientists are working hard on coronavirus vaccine and if their efforts bear fruit, COVID-19 warriors will be the first ones to get the dose, Union Minister of State for Health Ashwini Kumar Choubey said on Saturday. Interacting with report...

Germany defends calling Spain virus 'risk area'

Germanys health minister has defended the decision to declare all of mainland Spain and the Balearic Islands risk areas for coronavirus infection. Travellers must undergo compulsory testing and two-week quarantine after arriving from there....

PM to inaugurate 'Atal Tunnel' in Rohtang next month: Himachal CM on I-Day

Himachal Pradesh Chief Minister Jai Ram Thakur on Saturday said the Atal Tunnel in Rohtang would be inaugurated by Prime Minister Narendra Modi by the end of September this year. Thakur stated this while presiding over a state-leve...

Give Feedback