Jamaal Charles, signed to a one-year deal on Tuesday, could fight his way into the game plan with a good showing this week. T.J. Yeldon will start for Jacksonville.
The absence was expected after Fournette aggravated his hamstring injury in Week 4 against the New York Jets. He initially left the season opener against the New York Giants with the injury, missed two games and returned to face the Jets before bowing out yet again and missing Sunday's loss to the Kansas City Chiefs.
The Jaguars' depth at running back took a hit Sunday when Corey Grant went down with a Lisfranc foot injury that landed him on injured reserve. Grant has just 13 carries for 40 yards this season, but he also has nine catches for 67 yards and is a core member of the special teams.
Jacksonville has leaned heavily on Yeldon, who has 258 yards on 59 carries (4.4 average) and a touchdown along with 22 catches for 194 yards and three scores. That included an eight-catch, 69-yard day with a receiving touchdown at Kansas City.
The Jaguars also signed rookie seventh-round running back David Williams off the Denver Broncos' practice squad on Tuesday.
--Field Level Media
(With inputs from agencies.)