The painting which depicts a young boy's journey into adulthood covers the outside of giant storage containers in the port city of Incheon, west of Seoul, taking up 23,688 square meters.
The mural was commissioned by the city's government and port authority as part of efforts to improve the negative view of aged industrial facilities, an idea which originated from the community art projects of the 1920s that swept the United States and Mexico, according to the South's Yonhap news agency.
Twenty-two artists used more than 850,000 litres of paint to tell the story which reflects the seasons and resembles 16 individual book covers, at a cost of 550 million won (US$487,000).
Government and port officials also hope the mural will give a boost to tourism on Wolmi Island, one of the top tourist spots near Incheon.
(With inputs from agencies.)