Amgen issues 2021 outlook below Street view, halts cancer trials

U.S. biotech Amgen Inc on Tuesday provided a 2021 earnings forecast below Wall Street estimates and said it had paused or halted enrollment for clinical trials of three cancer drugs. Amgen reported a higher-than-expected profit for the fourth quarter, with adjusted earnings per share of $3.81 beating the average analyst estimate by 41 cents.

U.S. biotech Amgen Inc on Tuesday provided a 2021 earnings forecast below Wall Street estimates and said it had paused or halted enrollment for clinical trials of three cancer drugs. For 2021, Amgen forecast adjusted earnings of $16.00 to $17.00 per share, putting the midpoint well below analysts' estimates of $17.03 per share, according to IBES data from Refinitiv. The full-year revenue forecast of $25.8 billion to $26.6 billion was more in line with analyst projections of $26.45 billion.

"The 2021 outlook is light versus consensus but we believe they are generally being conservative," Jefferies analyst Michael Yee said in an email. Due to the COVID-19 pandemic, Amgen said physician-patient interactions remained below normal levels in the fourth quarter and it expects that to continue through 2021.

In a statement, the company said recovery in the latter part of the year is contingent on the speed and effectiveness of the global vaccination rollout. Amgen also said it had paused three clinical trials of early stage cancer drugs due to efficacy or safety issues.

The news "will make investors nervous about the pipeline and possibly drive further inquiry into whether they need to do more M&A," Yee said of deals and acquisitions. Amgen reported a higher-than-expected profit for the fourth quarter, with adjusted earnings per share of $3.81 beating the average analyst estimate by 41 cents. The number of Amgen shares outstanding fell 13% from a year earlier.

Net profit for the quarter fell 3% to $2.76 per share. Quarterly revenue rose 7% to $6.6 billion, in line with analysts’ estimates.

Sales of older rheumatoid arthritis drug Enbrel fell 5% to $1.27 billion, shy of analysts' estimate of $1.3 billion. Sales of newer migraine drug Aimovig totaled $104 million for the quarter, short of the $115 million projected by analysts. But sales of cholesterol fighter Repatha rose 27% to $253 million, beating Wall Street estimates of $223 million.

Sales of Neulasta, which fights infections by boosting white blood cells, fell 19% to $536 million, while sales of kidney drug Sensipar dropped 58% to $45 million in the face of increased competition from cheaper generics and biosimilars. Amgen shares were unchanged after hours from their close at $240.49.

(Reporting By Deena Beasley Editing by Bill Berkrot)