FACTBOX-Latest on the worldwide spread of the coronavirus

* India's richest state, Maharashtra, announced stringent COVID-19 restrictions from Monday, after a rapid rise in infections now accounting for more than half the country's daily new cases. * In Thailand, it's the all-important tourism sector that has jumped to the head of the COVID-19 vaccination line, with Phuket, the country's most popular resort island, embarking on a mass inoculation program two months ahead of the rest of the country.

India reported a record rise in coronavirus infections on Monday, becoming only the second country after the United States to register more than 100,000 new cases in a day, as hospitals in its worst affected state are overrun by patients. DEATHS AND INFECTIONS

* Eikon users, see COVID-19: MacroVitals https://apac1.apps.cp.thomsonreuters.com/cms/?navid=1592404098 for a case tracker and summary of the news. EUROPE

* The number of people in intensive care units in France rose by 68 to 5,341 on Sunday, official data showed, as the country entered its third coronavirus lockdown. * Portugal on Sunday extended restrictions on travel via land and sea to Spain that had been due to end this weekend until April 15.

* Bank of Italy Governor Ignazio Visco told the Financial Times newspaper that the biggest threat to a global economic recovery is the irregular pace at which countries are vaccinating their populations against COVID-19. AMERICAS

* The United States has put Johnson and Johnson in charge of a plant that ruined 15 million doses of its COVID-19 vaccine and has stopped British drugmaker AstraZeneca from using the facility, a senior health official said on Saturday. ASIA-PACIFIC

* Drugmaker Johnson & Johnson has filed its application for emergency use authorization of its COVID-19 vaccine in the Philippines, the country's Food and Drug Administration chief said on Monday. * India's richest state, Maharashtra, announced stringent COVID-19 restrictions from Monday, after a rapid rise in infections now accounting for more than half the country's daily new cases.

* In Thailand, it's the all-important tourism sector that has jumped to the head of the COVID-19 vaccination line, with Phuket, the country's most popular resort island, embarking on a mass inoculation program two months ahead of the rest of the country. * China reported its biggest daily jump in new COVID-19 cases in more than two months, as a city on the border with Myanmar in southwestern Yunnan province accounted for all new local cases.

* Thousands of Pakistanis rushed to get inoculated in the first round of commercial sales of COVID-19 vaccines that began over the weekend, with vaccination sites in the southern city of Karachi saying on Sunday they had already sold out. MIDDLE EAST AND AFRICA

* Turkey began administering Pfizer and BioNTech's COVID-19 shots, introducing the second vaccine in its campaign that began in mid-January, as new cases reached record highs. MEDICAL DEVELOPMENTS

* India's Cadila Healthcare Ltd has sought approval from local regulators to use a Hepatitis C drug as a treatment for COVID-19 following promising interim results from a late-stage trial, the drugmaker said. * Emergent BioSolutions Inc said late on Sunday that a key U.S. agency has increased an order, related to the manufacturing of J&J's COVID-19 vaccine, by $23 million.

* Emergent added it expects to align with the U.S. government and AstraZeneca to ramp down manufacturing for AstraZeneca's COVID-19 vaccine at its Baltimore plant. ECONOMIC IMPACT

* India's factory activity grew at its weakest pace in seven months in March as renewed lockdowns to curtail a resurgence in COVID-19 cases dampened domestic demand and output, a private survey showed. * Japan may need to compile a supplementary budget for the current fiscal year to combat the economic blow from the COVID-19 pandemic, a senior ruling party official was quoted as saying in a television program.

* U.S. President Joe Biden would be willing to push through his $2 trillion infrastructure plan without the support of Republican lawmakers if he cannot reach a bipartisan deal, Energy Secretary Jennifer Granholm said on Sunday.