Gene Deletion in Chromosome 22: Unlocking the Risk for Psychosis

A study by the University of Geneva explores how discrepancies between brain regions linked to a common gene deletion on chromosome 22 could help assess the risk for developing psychosis. The research followed 300 patients over 20 years, revealing significant brain coupling discrepancies that may serve as predictive markers.

Researchers at the University of Geneva have identified key discrepancies between brain regions linked to a common gene deletion affecting one in every 2000 individuals, which could help evaluate the risk of developing psychosis.

The study tracked 300 patients aged 5-34 for 20 years, focusing on the 22q11.2DS microdeletion. This genetic anomaly leads to heart defects and immune system issues, and about one-third of carriers develop psychotic disorders, including schizophrenia.

Using magnetic resonance imaging, scientists observed the development of brain region interactions over 12 years, identifying persistent discrepancies in the frontal, cingulate, and temporal cortices. These findings could pave the way for predictive markers to assess psychosis risk.

(With inputs from agencies.)