UK human 'challenge trial' launches to study COVID-19 reinfection

A year-long trial launched Monday to study how the immune system reacts in people contracting coronavirus for the second time.

ANI | London | Updated: 19-04-2021 21:10 IST | Created: 19-04-2021 21:10 IST
UK human 'challenge trial' launches to study COVID-19 reinfection
Representative Image. Image Credit: ANI

A year-long trial launched Monday to study how the immune system reacts in people contracting coronavirus for the second time. CNN reported that volunteers in the UK who've previously had Covid-19 will be deliberately infected with the virus to discover what it may mean for developing immunity.

The "challenge trial" will happen under carefully controlled conditions, with treatments on hand in case volunteers becomes ill, the team at the University of Oxford said. "Challenge studies tell us things that other studies cannot because, unlike natural infection, they are tightly controlled. When we re-infect these participants, we will know exactly how their immune system has reacted to the first Covid infection, exactly when the second infection occurs, and exactly how much virus they got," Dr. Helen McShane, a vaccine specialist at the University of Oxford, said in a statement.

CNN reported that the first phase of the study, starting this month, will find the lowest dose of virus that can infect half of the coronavirus survivors without causing symptoms. Then all 64 volunteers will be infected with that dose. Their immune responses will be studied. Participants will initially be monitored 24/7 for two weeks while they are in quarantine in a specially designed hospital suite where they will undergo medical tests, including CT scans of the lungs and MRI scans of the heart.

Any volunteers who develop symptoms will be treated with Regeneron's monoclonal antibody treatment and discharged from quarantine only when they are at no risk of infecting others. "One of the things we can determine with this study is how long that protection lasts. Once we understand exactly the immune response that protects against second infection, we can then use that information to develop vaccines more quickly, test vaccines more quickly, and understand who is protected and who isn't from this virus," McShane said in an interview with Radio 4 on Monday as reported by CNN.

McShane said they'll be recruiting people who are young and healthy - ages 18 to 30 -- with the "lowest possible risk of serious consequences from this infection." (ANI)

(This story has not been edited by Devdiscourse staff and is auto-generated from a syndicated feed.)


TRENDING

OPINION / BLOG / INTERVIEW

Blockchain in Healthcare: Opportunities and challenges

The use of blockchain in healthcare is a relatively new innovation with many of its uses still being explored and related technologies being developed, improved, and scaled. ...

Debate surrounding vaccine passports and development misses bigger picture

... ...

Blockchain vs IOTA: Looking for a better alternative

... ...

For stability, Iraq needs to crack down on corruption

... ...

Videos

Latest News

BJP accuses KCR of utilising official state machinery against Etela Rajender

Bharatiya Janata Party BJP leader NV Subhash on Wednesday accused Chief Minister K Chandrasekhar Rao KCR of utilising official state machinery against minister Etela Rajender, and said that he had stopped to the level of a gully leader. Ear...

Mexico's coronavirus death toll passes 218,000

Mexicos health ministry on Wednesday reported 267 new confirmed coronavirus deaths, bringing the total number of fatalities in the country to 218,007.Separate government data published in March suggested the real death toll may be at least ...

Australia races to trace source of COVID-19 mystery case in Sydney

Australian authorities were racing to track the source of a mystery COVID-19 infection in Sydney on Thursday, the first locally transmitted case in the city in more than a month, warning residents to brace for more cases.Health officials ar...

Andhra Police holds COVID-19 awareness rally as state observes partial lockdown

As part of the partial curfew and Section 144 imposed in Andhra Pradesh, the Srikakulam district police on Wednesday held a COVID-19 awareness rally with 10 vehicles in all major junctions of the town. Deputy Superintendent of Police Mahend...

Give Feedback