New Enzyme Discovery Sheds Light on Memory Updates in Aging Brains

Penn State researchers have identified an enzyme linked to declines in memory updating among older adults. Blocking histone deacetylase 3 (HDAC3) in mice led to improved memory updates, presenting potential therapeutic targets for enhancing cognitive flexibility and combating disorders such as Alzheimer's.

A groundbreaking study by Penn State researchers has unveiled an enzyme that may be the key to understanding age-related memory decline. Historical forgetfulness is not merely an inevitable aspect of aging; it stems from deeper molecular mechanisms, particularly involving memory updates.

The enzyme, histone deacetylase 3 (HDAC3), plays a significant role in gene transcription. The study, published in Frontiers in Molecular Neuroscience, found that blocking HDAC3 in older mice eliminated their typical memory updating deficits, allowing them to perform as well as younger mice.

'It's critical to understand what's happening at a molecular level during a memory update,' noted lead author Janine Kwapis. The findings could pave the way for advanced treatments aimed at improving cognitive flexibility in the elderly, potentially aiding conditions like Alzheimer's and dementia.

(With inputs from agencies.)