Left Menu
Development News Edition

IIT Delhi researchers developing technology for rapid diagnosis by reducing antibacterial resistance

PTI | New Delhi | Updated: 31-10-2019 16:09 IST | Created: 31-10-2019 16:06 IST
IIT Delhi researchers developing technology for rapid diagnosis by reducing antibacterial resistance
Image Credit: Wikipedia

Researchers at IIT Delhi are working on a technology to devise diagnostic solutions for combating the problem of antimicrobial resistance to enable rapid diagnosis of bacterial infection and guide clinical decision making. According to the team at IIT, the research will greatly reduce the unnecessary use of antimicrobials in diagnostic tests and minimise the development of resistance as currently there is a big knowledge gap in microbial resistance biology and the availability of biomarkers and technology for rapid diagnostics.

"Antibacterial resistance is now widely recognised as the biggest healthcare problem of this century. Due to limitations in the current microbiological methods, it is estimated that more than two-thirds of antibiotic prescriptions are unnecessary and are empirical in nature. This practice is a major cause of the emergence of AMR and its rapid spread in the last decade," said IIT professor Vivekanandan Perumal, who is the Principal Investigator (PI) of the project. "Although the requirement of rapid pathogen identification and methods for antimicrobial susceptibility testing (AST) are well recognized, major limitations include the knowledge gaps in understanding the genomic signatures and their correlation with Antimicrobial Resistance (AMR)," he added.

The research team will focus on 4 major pathogens (Staphylococcus aureus, Klebsiella pneumonia, Acinetobacter baumanii, Pseudomonas aeruginosa) that are often resistant to antibiotics in Indian clinical settings. The main objectives of the research project include -- characterization of AMR among Indian isolates using whole-genome sequencing of clinical isolates and optical genome mapping for pathogen identification using a unique genome-based signature for microbial typing with the optical mapping of DNA fragments.

"The research will also look into development of methods for rapid antimicrobial susceptibility testing by carrying out the pH measurements inside spherical microgels microreactors with embedded pH-sensitive carbon dot nanosensors and identification of bacteria species and spread of AMR using clothes worn by HCWs (healthcare workers) with a rapid culture-independent method based on bacterial 16s RNA," Perumal said.


TRENDING

OPINION / BLOG / INTERVIEW

Why COVID-19 is unstoppable in USA despite it being ranked at the top of GHS Index?

Several worst-hit countries such as Italy, France, Spain, the UK, Canada, and Russia have peaked COVID-19 cases in April. Almost all of them have gradually flattened the curve. However, the USA is setting new daily records of infections tha...

COVID-19 seems cooking biggest ever global scam

The increasing number of corruption cases on COVID-19 funds from throughout the world and involvement of high profile persons indicate that the countries cant ignore corruption in their pandemic response programs. This has generated the nee...

Health Management Information Systems lack holistic, integrated, and pandemic resilient character

Being a part of the United Nations system, the World Health Organization WHO deserves its share of rebuke for its alleged failure issue COVID-19 health emergency alerts on appropriate time. However, the pandemic has also exposed loopholes i...

Pride in the time of coronavirus: a welcome move online?

This year is different in many ways not least as celebrations are also taking place against the dramatic backdrop of a global health crisis and a resurgence in grassroots activism following the death of George Floyd in Minneapolis. ...

Videos

Latest News

FirstGroup says it may not survive as passenger numbers dive

British bus and train operator FirstGroup warned on Wednesday it might not survive as a going concern after a collapse in passenger numbers led to a 153 million pounds 192 million loss in the year to March, sending its shares down 15. But t...

NHL-Players' union executive board approves deal to resume ice hockey season

The NHL Players Association NHLPA executive board has approved a tentative agreement to resume the ice hockey season interrupted by the COVID-19 pandemic, it said late on Tuesday. The NHL had on Monday reached a tentative agreement with the...

FACTBOX-What we know about UK finance minister Sunak's spending plans

Finance minister Rishi Sunak will spell out new measures to revitalise Britains economy and protect jobs from the fallout of the COVID-19 pandemic when he updates parliament on Wednesday. Heres what we know already about Sunaks announcement...

China, U.S. trade tit-for-tat visa curbs over Tibet

China said on Wednesday it will impose visa restrictions on U.S. citizens who have engaged in what it called egregious behaviour over Tibet, in apparent retaliation against U.S restrictions on Chinese officials.U.S. Secretary of State Mike ...

Give Feedback