Brazilian midfielder Rafinha chosen in place of Messi to play against Real Madrid

Barcelona's Brazilian midfielder Rafinha was chosen in place of the injured Lionel Messi for Sunday's 'Clasico' against arch-rivals Real Madrid, as coach Ernesto Valverde kept faith with the same players who beat Inter Milan 2-0.

Barca is set to line-up in a 4-3-3 formation with Rafinha on the right, Luis Suarez as a central striker and record signing Philippe Coutinho on the left. Rafinha struck Barca's first goal in their Champions League victory over Inter on Wednesday.

The coach also rewarded in-form midfielder Arthur Melo for his recent displays, handing the Brazilian his first appearance in a 'Clasico'.

Under-fire Real coach Julen Lopetegui picked playmaker Isco in place of forwarding Marco Asensio in what is likely to be a four-man midfield, with Gareth Bale and Karim Benzema up front. Spain international Isco has recently returned to action from a month out following appendicitis.

Lopetegui, who Spanish media reported is facing the sack unless his side wins the game, selected Nacho at right back in place of the injured Dani Carvajal, and recalled Belgium goalkeeper Thibaut Courtois after fielding Keylor Navas in the 2-1 win over Viktoria Plzen on Tuesday.