Left Menu
Development News Edition

Insulin-producing beta cells may change function in diabetes: Study

They found that the RNA messaging system which tells proteins how to behave in cells is functioning differently in diabetes.

ANI | Washington DC | Updated: 18-05-2019 14:49 IST | Created: 18-05-2019 14:39 IST
Insulin-producing beta cells may change function in diabetes: Study
The study may give new insights into how high blood sugar can alter the behaviour of important hormone-producing cells, and pave the way to new treatments. Image Credit: Pixabay

Researchers revealed that insulin-producing beta cells can change their own function in diabetes. They found that the RNA messaging system which tells proteins how to behave in cells is functioning differently in diabetes. The changes lead to some of the beta cells no longer producing insulin which regulates blood sugar, and instead of producing somatostatin, which can block the secretion of other important hormones including insulin itself.

The study may give new insights into how high blood sugar can alter the behaviour of important hormone-producing cells, and pave the way to new treatments. Professor Lorna Harries, the lead researcher of the study, said: "These insights are really exciting. Only recently, Exeter researchers discovered that people with type 1 diabetes still retain some insulin-producing cells, but the environment produced by diabetes can be toxic for these cells that remain. Our work could lead to new changes to protect these cells, which could help people maintain some ability to make their own insulin. The method we used of creating an all-human cell system for the first time is significant - I don't think we'd have seen these changes in mouse cells."

The team then analysed post mortem pancreas tissue from people with either type 1 or type 2 diabetes. This revealed that they have more delta cells than they should have, suggesting that diabetes might be causing some of the beta cells to turn into delta cells in people as well as in cells in the laboratory. "The really exciting finding is that in the laboratory at least, we have been able to reverse the changes - turn the delta cells back to beta cells - if we restore the environment to normal, or if we treat the cells with chemicals that restore the regulator genes and the patterns of RNA messages made to normal. That's very promising when we consider the potential for new therapeutics," concluded Professor Harries. (ANI)


TRENDING

OPINION / BLOG / INTERVIEW

International Day of Non-Violence: Rising crimes against animals call for 'Ahimsa' redux

2020 has seen some of the most horrific incidents of animal-directed violence in India. The only silver lining - if you will - is the wave of backlash that not only sparked awareness for the prevention of animal cruelty, but also a sensibil...

South Africa's COVID-19 response: Surprising outcomes or just poor data management?

South Africa has been committed to improving its health information system and shows that a robust digital has considerable scope to improve healthcare for the entire population. But the COVID-19 pandemic has highlighted that significant ga...

Post-COVID-19 Nigeria needs a robust Health Management Information System to handle high disease burden

Nigeria is among a few countries that conceptualised a health management information system HMIS in the early 90s but implementation has been a challenge till date. Besides COVID-19, the country has a huge burden of communicable and non-com...

Morocco COVID-19 response: A fragile health system and the deteriorating situation

Learning from its European neighbors, Morocco imposed drastic measures from the initial stages of the COVID-19 outbreak to try to contain its spread. The strategy worked for a few months but the cases have surged after mid-June. In this sit...

Videos

Latest News

47 fresh coronavirus cases in UP's Muzaffarnagar

Forty-seven fresh cases of COVID-19, including eight prison inmates, were reported here taking the number of active patients to 900 in the district on Thursday, officials said. With eight prisoners testing positive for the virus, a total of...

Bharti never made statement taking responsibility for demolition of structure at Ayodhya: ASG

A law officer Thursday asserted that BJP leader Uma Bharti never made any statement taking any responsibility for the demolition of the disputed structure at Ayodhya in 1992 and refuted reports about Justice M. S. Liberhans remarks in ...

Those who backed Kangana should speak up for Hathras victim: Raut

Shiv Sena MP Sanjay Raut on Thursday said those who attacked his party for demolition at actor Kangana Ranauts bungalow should now demand justice for the Hathras rape-and-murder victim. He also criticized the alleged rough treatment meted o...

PM speaks to Solanki after Cong leader recovers from COVID-19

Prime Minister Narendra Modi on Thursday spoke to Gujarat Congress leader Bharat Solanki, who has recovered from COVID-19 after a over 100-day-long battle, and said that he has shown remarkable courage in fighting the disease. In a tweet, ...

Give Feedback