HIGHLIGHTS-Tennis-US Open day four

Highlights of the fourth day at the U.S. Open at Flushing Meadows on Thursday (times GMT): 0510 MEDVEDEV SEES OFF O'CONNELL

Former champion Daniil Medvedev recorded his 250th win on hard courts after securing a late-night 6-2 6-2 6-7(6) 6-2 victory over Australia's Christopher O'Connell in the second round. "At one moment in the match he decided to play better," Medvedev joked in his on-court interview. "I played the same from the first point to the last. It became much tougher for me, so I'm happy that I was able to still hang in there."

The Russian world number three will next face Argentina's Sebastian Baez. 0332 PEGULA CRUISES INTO THIRD ROUND

World number three Jessica Pegula, the top-ranked American in the draw, breezed past Romania's Patricia Maria Tig 6-3 6-1 to reach the third round, where she faces Elina Svitolina of Ukraine. READ MORE

Alcaraz and Medvedev move on at U.S. Open as Isner exits with a bang Order of play on Friday

Medvedev survives 'Aussie' late night scare to advance at US Open 'Zombie'

Jabeur refuses to let illness defeat her at US Open

Alcaraz downs Harris to reach US Open third round 'Warrior' Jabeur battles past Noskova to reach US Open third round

Pegula crushes Tig to set up Svitolina showdown in New York Svitolina outplays Pavlyuchenkova to reach US Open third round

Deep runs at majors may be out of reach, says Murray Ace king Isner calls it a career after U.S. Open loss

Murray, Isner come up short U.S. Open second round Dimitrov overwhelms Murray, Draper upsets Hurkacz

Sabalenka powers past Burrage into U.S. Open third round Djokovic, Swiatek advance before China's Zhang shocks Ruud at US Open

Wozniacki's US Open return continues with Kvitova upset Fritz, Gauff lead American charge at US Open

0208 JABEUR GETS PAST NOSKOVA Tunisian fifth seed Ons Jabeur, last year's runner-up, earned a 7-6(7) 4-6 6-3 win over Czech teenager Linda Noskova in the second round. She will next face another Czech player, Marie Bouzkova.

0148 ALCARAZ BEATS HARRIS Defending champion Carlos Alcaraz prevailed in a tough third set against South Africa's Lloyd Harris to seal a 6-3 6-1 7-6(4) win and reach the third round, where he will face Britain's Dan Evans.

0145 KASATKINA HOLDS OFF KENIN Russian 13th seed Daria Kasatkina earned a 2-6 6-4 6-4 second-round win over home hope Sofia Kenin, whose Australian Open triumph in 2020 was the last time a U.S. player won a Grand Slam.

2337 RUBLEV DOWNS MONFILS Russian eighth seed Andrey Rublev overcame a third-set wobble to beat Frenchman Gael Monfils 6-4 6-3 3-6 6-1.

2306 WAWRINKA KEEPS ON ROLLING Swiss 38-year-old and former U.S. Open champion Stan Wawrinka claimed a hard-fought 7-6(6) 6-7(7) 6-3 6-2 win over Argentine Tomas Etcheverry.

The three-time Grand Slam winner will face Italian sixth seed Jannik Sinner in the third-round. 2205 SVITOLINA FIGHTS BACK, NORRIE SAFELY THROUGH

Ukraine's former semi-finalist Elina Svitolina battled back from a set down to take victory over Russia's Anastasia Pavlyuchenkova 5-7 6-4 6-4. Briton 16th seed Cameron Norrie toppled qualifier Hsu Yu Hsiou of Taiwan 7-5 6-4 6-4 6-4.

2055 VONDROUSOVA EASES PAST TREVISAN Czech ninth seed and Wimbledon champion Marketa Vondrousova claimed a comfortable 6-2 6-2 win over Italy's Martina Trevisan to reach the third round.

2034 UNTROUBLED KEYS, DE MINAUR ADVANCE American 17th seed and former finalist Madison Keys outclassed Yanina Wickmayer of Belgium 6-1 6-2 in under an hour.

Australian Alex de Minaur, the men's 13th seed, crushed China's Yibing Wu 6-1 6-2 6-1. 1940 BERRETTINI WITHDRAWS

Former U.S. Open semi-finalist Matteo Berrettini of Italy was forced to withdraw from his second-round match against Arthur Rinderknech after falling and sustaining an ankle injury. Frenchman Rinderknech won the first set 6-4 and was serving to take the second.

1920 ISNER RETIRES FROM TENNIS WITH LOSS TO MMOH American John Isner brought the curtains down on his 17-year professional career, losing to compatriot Michael Mmoh who rallied from two sets down to win 3-6 4-6 7-6(3) 6-4 7-6(10-7).

"It's tough. I like to think I worked as hard as I could," said a tearful Isner. "To play in front of this crowd and have this support is pretty special. Thank you." 1900 DIMITROV OUTCLASSES MURRAY. SABALENKA, ZVEREV WIN

Bulgarian 19th seed Grigor Dimitrov booked his place in the third round with a crushing 6-3 6-4 6-1 win over former U.S. Open champion Andy Murray. German Alexander Zverev, the 12th seed, overcame compatriot Daniel Altmaier 7-6(1) 3-6 6-4 6-3.

Australian Open champion and second seed Aryna Sabalenka of Belarus beat Britain's Jodie Burrage 6-3 6-2. 1730 SINNER EASES PAST SONEGO, DRAPER THROUGH

Sixth seed Jannik Sinner earned a comfortable 6-4 6-2 6-4 win over Lorenzo Sonego in an all-Italian second-round clash. Briton Jack Draper upset 17th seed Hubert Hurkacz of Poland 6-2 6-4 7-5 to reach the third round.